5-Hydroxytryptophan (5-HTP), is a naturally-occurring amino acid and chemical precursor as well as metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.

Description: Immediate precursor to serotonin extracted from Griffonia simplicifolia plant.

Method of Action: Stimulates brain serotonin levels by increasing cellular serotonin output. In double-blind, multi-center controlled study 5-HTP was found as effective (at dosage level below) to the SSRI drug fluvoxamine (Luvox). Research studies have found elevated levels of serotonin in the cerebral spinal fluid after ingestion of 5-HTP without a rise in platelet 5-HT indicating inhibition of peripheral decarboxylation. Elevations in cortisol, human growth hormone and prolactin have been reported in multiple studies. 5-HTP appears to be associated with a drop in core body temperature in males and a rise in core body temperature in females.

Indications and Potential Usage: Depression; Anxiety; Possibly Obsessive-Compulsive Disorder; Insomnia; Fibromyalgia; Alcohol Withdrawal; Weight Loss; Migraine Headache; Weight Loss

Contraindications: Do not use this product if you are pregnant or lactating without first seeking advice from your physician. Scleroderma patients should take 5-HTP only under close medical supervision. Do not use this product if you have a predisposition to high blood pressure, heart disease, cancer, or autoimmune disease. Persons with liver damage should not consume 5-HTP. Persons have experienced a rash, difficulty breathing, or flushing of the skin associated with 5-HTP use should discontinue use of this product.

Dosage and Administration: Effective 5-HTP dosage varies widely. Initial recommended dose: 50mg with each of three meals. For optimal 5-HTP absorption meal proceeding should be low in protein and high in carbohydrates. If you do not experience results in 7 days you may increase 5-HTP to 100 mg three times daily. Some research studies have used 600 mg per day and this dosage should not be exceeded. To increase absorption of 5-HTP take vitamins B6 (25-50 mg) - a cofactor that degrades toxic tryptophane metabolites and aids in conversion of 5-HTP to serotonin - Vitamin C (200-500 mg) and magnesium (10 mg) at least 30 minutes before or after 5-HTP dosing. Alcohol should be avoided within 6 hours of 5-HTP use.

Clinical Effect In: Some mood elevation effects are often reported within 30 to 90 minutes. Main effect varies widely based on physical condition of the patient and the disorder being treated. A clinical reponse is likely in several days to two weeks.

Known Interactive Effects: Do not initiate use within 4 weeks of taking another serotonin enhancing drug or use in conjunction with bright light phototherapy without professional supervision. Do not initiate use until 4 weeks after discontinuing use of a MAOI medication under any circumstances. Do not use if pregnant or nursing. Not for use by children under 14 years of age. Do not use in combination with weight loss drugs, L-dopa, tricyclic or other antidepressant medications, high doses of antihistamines, illegal drugs cancer chemotherapy or (possibly) antibiotic medications.

Additional Considerations: Some studies suggest 5-HTP eventually loses agnostic serotonergic effect and becomes a serotonin antagonist. Use enteric coated product that doesn't dissolve in stomach. Always consult a physician who is familiar with this product and it's possible immunological side effects before use. High quality 5-HTP products: Allergy Research Group, NF Formulas. Possible other good quality sources: Hypericum Buyers Club, Nature's Way, Natrol, Weider Nutritional, Now Natural Foods, Life Enhancement.

Warnings: The information above is provided for educational purposes and may not be construed as a medical prescription or as a substitute for the advice of your physician. Do not use this product without first consulting your physician especially if you are pregnant or lactating. Be advised that some herbs and dietary supplements can cause severe allergic reactions in some individuals and may also have an adverse result in conjunction with other medications, or treatments. You should regularly consult your physician in matters regarding your health and particularly in respect to symptoms and conditions which may require diagnosis or medical attention. Reevaluate use of this product after 6 months.